What happened on this land around c. 100–1 BCE?

Rome–Parthia rivalry defines geopolitics; Silk Road begins linking East to West.
Rulers
Parthian Empire
247 BCE–224 CE
Strong Iranian power balancing Rome in the west and steppe nomads in the east.
Battles
Battle of Carrhae
53 BCE
Parthians destroy Roman army under Crassus using cavalry and archery.